翻訳と辞書 Words near each other ・ Proton Synchrotron Booster ・ Proton therapy ・ Proton Tiara ・ Proton Waja ・ Proton Wira ・ Proton-coupled electron transfer ・ Proton-coupled folate transporter ・ Proton-dependent oligopeptide transporter ・ Proton-enhanced nuclear induction spectroscopy ・ Proton-gated urea channel ・ Proton-K ・ Proton-M ・ Proton-PM ・ Proton-pump inhibitor ・ Proton-pumping pyrophosphatase ・ Proton-sensing G protein-coupled receptors ・ Proton-to-electron mass ratio ・ Proton-transfer-reaction mass spectrometry ・ Proton200k ・ Protonaegleria ・ Protonarthrini ・ Protonarthron ・ Protonation ・ Protonebula ・ Protonebula altera ・ Protonectarina ・ Protonema ・ Protonemacheilus longipectoralis ・ Protoneura ・ Protoneura capillaris Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Proton-sensing G protein-coupled receptors ： ウィキペディア英語版 Proton-sensing G protein-coupled receptors Proton-sensing G protein-coupled receptors are transmembrane receptors which sense acidic pH and include GPR132 (G2A), GPR4, GPR68 (OGR1) and GPR65 (TDAG8). These G protein-coupled receptors are activated when extracellular pH falls into the range of 6.4-6.8 (typical values are above 7.0). The functional role of the low pH sensitivity of the proton-sensing G protein-coupled receptors is being studied in several tissues where cells respond to conditions of low pH including bone and inflamed tissues. The four known proton-sensing G protein-coupled receptors are Class A receptors in subfamily A15. == Nociception == Pain sensation can be initiated by nociceptor cells that are sensory neurons with cell bodies located in the dorsal root ganglia. Some nociceptors respond to low pH and the pH-sensitive amiloride-sensitive cation channel 3 has been described as a modulator of acid-induced pain sensation. However, results with amiloride-sensitive cation channel 3 gene knockout mice suggest that those channels do not fully account for acid-induced pain sensation. Proton-sensing G protein-coupled receptors have been shown to be expressed in small-diameter neurons responsible for nociception where they may play a role in acid-induced pain sensation. Acid-sensing neuron-mediated immediate pungent pain has been associated with acid-sensing ion channels. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Proton-sensing G protein-coupled receptors」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.